Blar i forfatter "Bugno, Ryszard"

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    • Inhibition of PDE5A1 guanosine cyclic monophosphate (cGMP) hydrolysing activity by sildenafil analogues that inhibit cellular cGMP efflux 

      Subbotina, Anna; Ravna, Aina Westrheim; Lyså, Roy Andre; Abagyan, Ruben; Bugno, Ryszard; Sager, Georg (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-17)
      <p><i>Objectives</i>: To determine the ability of 11 sildenafil analogues to discriminate between cyclic nucleotide phosphodiesterases (cnPDEs) and to characterise their inhibitory potencies (<kursiv>K</kursiv><sub>i</sub> values) of PDE5A1‐dependent guanosine cyclic monophosphate (cGMP) hydrolysis.</p> <p><i>Methods</i>: Sildenafil analogues were identified by virtual ligand screening (VLS) ...